
Bi-Est Hormone Cream
A compounded cream combining estriol and estradiol, with progesterone or testosterone as your provider prescribes.
- Licensed provider review
- Medication shipped to your door
- Free, discreet shipping
- Dose guidance from your provider
- Ongoing care team support
- Full refund if not approved
Prescription required. A licensed provider decides whether treatment is right for you. See important safety information.
Why people choose Bi-Est Hormone Cream
Customized formula
Made for your symptoms.
May ease hot flashes and sleep problems
Common menopause symptoms.
Easy to apply
A daily cream.

What is Bi-Est Hormone Cream?
Bi-Est combines two estrogens, estriol and estradiol, usually in an 80:20 or 50:50 ratio. Compounded creams can also include progesterone or a small amount of testosterone. Your provider customizes the formula for your symptoms.
Who Bi-Est Hormone Cream may be right for
It may be a fit for
- Women with perimenopause or menopause symptoms
Talk to your provider first if you
- Have a history of breast or uterine cancer
- Have had blood clots or a stroke
- Have liver disease
- Have unexplained vaginal bleeding
Prepared by licensed US pharmacies
Your medication is prepared by a state-licensed US pharmacy and checked against standard quality measures before it ships.
Three steps, 100% online
Take the free assessment
Tell us about your health history and goals. It takes about five minutes.
Provider review
A licensed provider in your state reviews your information and decides whether treatment is right for you.
Delivered to your door
If prescribed, your medication ships from a US-licensed pharmacy in discreet packaging.
Bi-Est Hormone Cream questions
How do I take it?
Applied to the skin as your provider directs. Wash your hands after each use.
Is Bi-Est Hormone Cream FDA-approved?
Compounded medications are prepared by licensed pharmacies for individual patients and are not reviewed or approved by the FDA for safety, effectiveness or quality.
What if I’m not approved?
If a provider decides it isn’t right for you, you get a full refund.
Important safety information
Serious side effects can include
- Blood clots
- Stroke or heart attack
- Breast or uterine cancer risk
Common side effects
Breast tenderness, headache, skin irritation and spotting.
Before you start
Tell your provider about all your health conditions and medications, including supplements.
This is not a complete list of risks. Talk to your provider about your health history before starting any treatment.


